Life Medcine第3卷第1期

近日，Life medicine第3卷第1期正式在線發(fā)布。本期共收錄新聞?dòng)^點(diǎn)（News & Opinion）2篇、亮點(diǎn)（Research Highlight）2篇、論壇（Forum）1篇、綜述（Review）2篇、研究長文（Article）2篇以及研究短文（Letter）1篇。

Life Medicine 第3卷第1期封面

On the Cover

Under physiological conditions, the liver possesses a strong potential for repair and regeneration after injury. However, with aging, these potential declines, and factors such as alcohol, drug, toxins, and other harmful substances can accelerate liver aging and induce a series of pathological features associated with aging-related liver diseases. These features include reduced liver volume, decreased blood flow, exacerbated inflammatory responses, and even increased fibrosis. These changes can impair the liver’s regenerative capacity to varying degrees, much like the wilting process of plant veins. A profound understanding of these pathological processes will aid in uncovering the mechanisms of liver aging and aging-related diseases and in exploring strategies to slow aging and promote liver health, allowing the tree of life to remain evergreen.

本期封面

肝臟在生理?xiàng)l件下具有強(qiáng)大的損傷后修復(fù)和再生潛能。增齡會(huì)讓這些潛能下降，酒精、藥物、毒物等因素會(huì)進(jìn)一步加快肝臟衰老的進(jìn)程并誘發(fā)肝臟出現(xiàn)一系列衰老相關(guān)疾病的病理特征，如肝體積減少、血流量降低、炎癥反應(yīng)加劇，甚至纖維化程度增加等。這些變化不同程度影響肝臟再生能力，正如植物脈絡(luò)的枯萎過程。深刻理解這些病理過程將助力我們揭示肝臟衰老及衰老相關(guān)疾病的機(jī)制，并探究延緩衰老促進(jìn)肝臟健康的策略，讓生命之樹常青。

1

News & Opinion

Deciphering microbiota-host interplay: bacterial metabolites and protein post-translational modifications

微生物和宿主的相互作用

From clones to synthetic embryos

克隆的前世今生和未來應(yīng)用

2

Research Highlight

Programmable G-to-Y base editing using engineered DNA glycosylase

非脫氨酶依賴的新型單堿基編輯工具

Tuning mitochondrial dynamics for aging intervention

調(diào)控線粒體動(dòng)力學(xué)以干預(yù)衰老

3

Forum

A biomarker framework for liver aging: the Aging Biomarker Consortium consensus statement

中國衰老標(biāo)志物聯(lián)合體發(fā)布肝臟衰老標(biāo)志物專家共識

4

Review

When synthetic biology meets medicine

合成生物學(xué)與醫(yī)學(xué)

Osteoporosis under psychological stress: mechanisms and therapeutics

心理應(yīng)激與骨質(zhì)疏松的聯(lián)系與治療

5

Article

Tracing TMEM106B fibril deposition in aging and Parkinson’s disease with dementia brains

TMEM106B聚集體在衰老和帕金森病癡呆人腦中的特征

Follicular fluid-derived exosomes rejuvenate ovarian aging through miR-320a-3p-mediated FOXQ1 inhibition

年輕人卵泡液外泌體miR-320a-3p通過靶向FOXQ1延緩卵巢衰老

6

Letter

Modeling antiviral response in the liver using human pluripotent stem cell-derived macrophages

人多能干細(xì)胞衍生的巨噬細(xì)胞-肝細(xì)胞共培養(yǎng)模型研究肝炎病毒感染

Life Medicine第3卷第1期網(wǎng)站鏈接：

https://academic.oup.com/lifemedi/issue/3/1